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Workplace learning and development is crucial for sustained employability, especially for people with limited work capacity (LWC). We explored the development in cognitive functioning and work behavior of people with LWC and to which extent this is moderated by workplace acceptance and support. As suggested in literature, acceptance and support concern pre-conditions for development. Therefore, we expected them to influence the development of our target group. In total, 182 people with LWC and 172 workplace mentors provided data on dimensions of cognitive functioning and work behaviour on three time-points over 4 months. Furthermore, people with LWC provided data on workplace acceptance and support. Results showed significant development over time for both, self- and observer-rated cognitive functioning, such as planning and organising, learning and memory, problem solving, and for self-rated adaptability and concentration. Development over time emerged for the self-rated work pace, a work behaviour dimension. Moreover, the growth curves on self-rated variables such as learning and memory, work accuracy, social behaviour and work pace were moderated by workplace acceptance and support. This study provides initial insight into growth patterns of cognitive functioning and work behaviour of people with LWC and illustrates the relevance of a supportive climate for development.